What is Lorazepam

• Generic Name: Lorazepam
• Common Brand Names: Ativan, Loreev XR
• Pronunciation: AT-ivan, lor-A-ze-pam, or-EEV ECKS-AR
• Drug Classes: Anticonvulsant, Anxiolytic, Benzodiazepine
• Availability: Prescription only; controlled substance; generic forms available for some formulations

Uses of Lorazepam

It is primarily prescribed for:

• Anxiety Disorders: Helps alleviate symptoms of anxiety.
• Status Epilepticus: A specific type of seizure that requires immediate treatment, typically administered via injection.

It may also be used for other conditions as determined by your healthcare provider.

How Lorazepam Works

Lorazepam exerts a calming effect on the brain and nervous system, which aids in reducing anxiety symptoms and controlling seizures.

Dosage Forms

It is available in various forms, including:

• Extended-Release Oral Capsules: 1 mg, 1.5 mg, 2 mg, 3 mg
• Oral Concentrate: 2 mg/mL
• Oral Tablets: 0.5 mg, 1 mg, 2 mg
• Injectable Forms: For intravenous or intramuscular use

Storage Instructions

• Oral Tablets and Extended-Release Capsules: Store at room temperature (68°F to 77°F or 20°C to 25°C). They can tolerate short-term exposure to temperatures between 59°F to 86°F (15°C to 30°C). Keep in a cool, dry place.
• Oral Concentrate and Injection: Store in the refrigerator (36°F to 46°F or 2°C to 8°C) and protect from light.

Common Side Effects

The most frequently reported side effects of lorazepam include:

• Drowsiness or sleepiness
• Dizziness
• Weakness
• Difficulty with balance or coordination

If you experience any bothersome side effects, consult your healthcare provider.

Serious Side Effects

While less common, serious side effects can occur, including:

• Allergic Reactions: Symptoms may include difficulty breathing, swelling of the face or throat, and hives. Seek immediate medical attention if these occur.
• Suicidal Thoughts: Some individuals may experience increased thoughts of self-harm. Contact your healthcare provider if you notice any changes in mood or behavior.
• Risk of Misuse: Misusing lorazepam can lead to severe consequences, including coma or death. Always take it as prescribed.
• Dependence and Withdrawal: Stopping lorazepam suddenly can lead to withdrawal symptoms. Consult your healthcare provider for a safe tapering plan.

Warnings and Precautions

Who Should Avoid Lorazepam?

• Individuals with allergies to lorazepam or other benzodiazepines.
• Those with acute narrow-angle glaucoma.

Important Considerations:

• Only use lorazepam if prescribed by a healthcare provider.
• Keep it out of reach of children, as it is a controlled substance that can lead to misuse.
• Be cautious when driving or performing tasks that require alertness until you know how lorazepam affects you.

What to Discuss with Your Healthcare Provider

Before using medicine, inform your healthcare provider about all your health conditions and any medications or supplements you are taking. Key points to discuss include:

• Mental Health History: Share any past or current mental health issues, especially thoughts of self-harm.
• Substance Use: Disclose any history of drug or alcohol misuse.
• Current Health Conditions: Inform your provider if you have liver or kidney issues, lung diseases, seizures, or sleep apnea.

Pregnancy and Breastfeeding

The effects of lorazepam during pregnancy are not fully understood. Using it in later stages of pregnancy may lead to withdrawal symptoms in newborns. Discuss with your healthcare provider if you are pregnant or planning to become pregnant.

Lorazepam can pass into breast milk, potentially affecting a nursing infant. Consult your healthcare provider about the safety of using lorazepam while breastfeeding.

Interactions with Other Substances

Food and Drink Interactions

There are no known interactions between lorazepam and foods or non-alcoholic beverages. However, avoid alcohol, as it can increase the risk of severe side effects.

Drug Interactions

Always inform your healthcare provider about all medications, including over-the-counter drugs, vitamins, and herbal supplements. Notable interactions include:

• Opioids (e.g., oxycodone, morphine)
• Other medications that cause drowsiness
• Flumazenil (used for benzodiazepine overdose)
• Valproic acid (for bipolar disorder and seizures)
• Clozapine (for schizophrenia)

This is not an exhaustive list of potential interactions. Always consult your healthcare provider for personalized advice.

Conclusion

Lorazepam is an effective medication for managing anxiety and seizures, but it requires careful monitoring and responsible use. Always follow your healthcare provider’s instructions and report any unusual symptoms or concerns.